Creatine is naturally produced in the human body from amino acids l-arginine, glycine, and l-methionine primarily in the kidney and liver and transported in the blood to help supply energy to all cells in the body. Creatine is metabolized into phosphocreatine, an important storage form used by the brain, heart, and skeletal muscles. 1-5 in normal healthy individuals, muscle creatine is replenished at a rate of approximately two grams a day. 6 creatine exerts various effects upon entering the muscle. It is these effects that elicit improvements in exercise performance and may be responsible for the improvements of muscle function and energy metabolism seen under certain conditions. Several mechanisms have been proposed to explain the increased exercise performance seen after creatine intake: 7 optimizing energy metabolism by maintaining higher levels of the body’spound adenosine triphosphate or atp. 8-10 increasing myofibrillar mrna content and protein synthesis, and reducing amino acid oxidation and protein break-down.
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